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Pragmatic trials are those that are designed to inform the practice of clinical trials in real life. They are usually characterized by a focus on the practical aspects of the research design, like the recruitment process and consent as well as adherence to the use of standard equipment.

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A pragmatic study that involves various investigators and participants from different geographical areas is the Home Blood Pressure Management study (HBPM). This type of heterogeneity is essential for practical trials to be valid and also helps reduce the chance of bias in the results. Too much heterogeneity, however can result in problems with the trial design.

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The aim of pragmatic trials is to replicate real-life scenarios and gain the highest level of validity externally. They are typically commissioned by policymakers and practitioners to help inform their decisions. They can be used to determine the cause-effect relationship of an intervention and its results. They should, however, not, 프라그마틱 슬롯 팁 be used to replace the need for explanation studies.

The concept of pragmatism is controversial, and there are doubts about whether pragmatic trials should replace explanatory trials or complement them. Schwartz and Lellouch1 suggested the distinction between explanation studies, which prove the physiological hypothesis or clinical hypothesis, as well as pragmatic trials that aid in policy and practice decision-making. They also suggested a framework dubbed PRECIS for pragmatic trials.2 The tool was designed to define the characteristics of a pragmatic research study that includes recruitment, design, implementation of the intervention, and follow-up.

There is a growing increase in the number of pragmatic trials that are published. A recent Medline search using the terms pragmatic and naturalistic, restricted to controlled trials that are randomized (RCTs) resulted in 34 articles, which are shown in red in Figure 2. This suggests that the health sciences community has become more aware of the importance of pragmatism. However, it is important to remember that the majority of these trials were conducted in primary care settings.