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Clinical trials that are designed to help inform practice in the real world are known as pragmatic trials. They are often described by their focus on practical aspects of study design that include the recruitment and consent process, as well as adherence and the use routinely available equipment.

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Another example of a pragmatic trial is the Home Blood Pressure Management (HBPM) study, 프라그마틱 정품 사이트 게임 (visit the next website) which utilized a variety of investigators and had participants from various geographical areas. This kind of heterogeneity, which is essential for pragmatic trials to be valid and lessen the chance of bias, is also necessary. A high degree of heterogeneity, however can result in problems with the design of the trial.

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Pragmatic trials aim to mimic real-life situations and attain maximum external validity. They are usually commissioned by policy makers and practitioners to aid in their decision-making. They also provide a useful method of determining the causality between an intervention and its outcomes. However, they should not be used in lieu for explanation studies.

The pragmatism concept is controversial, and there are doubts about whether pragmatic trials should replace or complement them. Schwartz and Lellouch1 proposed an distinction between explanation-based studies, which support the physiological hypothesis or clinical hypothesis, and pragmatic trials, that inform the decision-making process for policy and practice. They also suggested the framework for pragmatic trials, which they called PRECIS.2 This tool was designed to define the elements of a pragmatic trial which includes recruitment, design and delivery of the intervention, as well as the follow-up.

There is a positive trend in the number of pragmatic trials that are published. A recent Medline query that used the words naturalistic and pragmatic, restricted to randomised controlled trials (RCTs) returned 34 articles. These are shown in red on Figure 2. This indicates that the health sciences community is becoming increasingly sensitized to the issue of pragmatism. It is important to note that the majority of studies were conducted in primary care settings.