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Trials designed to inform clinical practice in the real world are referred to as pragmatic trials. They are often characterized by their focus on practical aspects of designing a study which include the recruitment and consent process, as well as adherence and the use routinely available equipment.

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A pragmatic study that involves various investigators and participants from different geographical areas is the Home Blood Pressure Management study (HBPM). This kind of heterogeneity is necessary for pragmatic trials to be able to prove their validity, and it also helps reduce the chance of bias in the results. A high degree of heterogeneity, however, can cause problems with the trial design.

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Pragmatic trials seek to replicate real-life situations and attain maximum external validity. They are usually requested by practitioners and policymakers to help guide their decisions. They are also a good method of determining the cause-effect relationship between the intervention and its effects. However, 프라그마틱 슬롯무료 (click through the following page) they shouldn't be used as a substitute for explanation studies.

The pragmatism idea is controversial and there are doubts about whether pragmatic trials should be used to replace explanatory trials or complement them. Schwartz and Lellouch1 suggested a distinction between explanatory trials, which prove the clinical or physiological hypothesis, and pragmatic trials that inform the policy and practice of. They also proposed an approach to pragmatic trials, called PRECIS.2 This tool sought to define the characteristics of a pragmatic trial, including the recruitment process, the design and implementation of the intervention, as well as follow-up.

There is a positive trend in the number of pragmatic trials published. A recent Medline search using the keywords pragmatic and naturalistic, restricted to randomized controlled trials (RCTs), yielded 34 articles, which are shown in red in Figure 2. This suggests that the health sciences community has become more aware of the importance of pragmatic thinking. However, it is important to note that the majority of these studies were conducted in primary care settings.