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Clinical trials that are designed to help inform practice in the real world are called pragmatic trials. They are typically described as a focus on the practical aspects of study design that include the recruitment and 프라그마틱 무료체험 consent process, as well as adherence and the use of standard equipment.

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A pragmatic trial that uses various investigators and participants from diverse geographical locations is the Home Blood Pressure Management study (HBPM). This type of heterogeneity, which is vital for pragmatic trials to be reliable and reduce bias in results is also essential. However too much heterogeneity could lead to issues with the design of the trial.

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The purpose of pragmatic trials is to replicate real-life scenarios and gain maximum validity externally. Usually, they are requested by practitioners and policymakers to help guide their decisions. They can also be used to assess the causal relationship between an intervention and its results. However, they should not, be used to replace explanatory studies.

The concept of pragmatism is controversial and there are concerns about whether pragmatic trials should replace or complement them. Schwartz and Lellouch1 made an distinction between explanation-based studies, which confirm a physiological hypothesis or clinical hypothesis, as well as pragmatic trials that aid in the decision-making process for policy and practice. They also suggested the framework for pragmatic trials, dubbed PRECIS.2 This tool sought to define the features of a pragmatic study which includes the recruitment process, the design and delivery of the intervention, as well as monitoring.

The number of pragmatic trials is growing. A recent Medline search using the terms naturalistic and pragmatic, which was limited to controlled trials randomized to control (RCTs) resulted in 34 articles, as shown in red in Figure 2. This is an indication that the health science community is becoming more acquaint to the subject of pragmatics. It is important to keep in mind that the majority of these trials were conducted in primary care settings.